Prof. Dr.

Prof. Dr.


Prof. Dr. Sema S. HAKKI
Selçuk Üniversitesi Diş Hekimliği Fakültesi

Periodontoloji

Diş Hekimliğinde Kök Hücre Uygulamaları Nerede?

Kök hücreler, embriyonik kök hücre, indüklenmiş pluripotent kök hücre ve mezenkimal kök hücreler olarak sınıflandırılmaktadır. Embriyonik kök hücreler, etik nedenlerle araştırma amaçlı bile kullanımına pek çok ülkede izin olmayan hücre grubudur. İndüklenmiş pluripotent kök hücreler ile ilgili çalışmalar ise laboratuvar aşamasındadır. Mezenkimal kök hücre kullanımını kapsayan hücre temelli tedaviler, tıpta farklı uygulama alanları bulmakla birlikte, diş hekimliğinde biraz daha yavaş ilerlemektedir.  Son 5 yılda, kök hücre temelli pulpa rejenerasyonuna yönelik insan vaka-serileri literatürde yayınlanmaktadır ve sonuçları son derece umut vericidir. Aynı şekilde, sinüs tabanı modifikasyonu, kret ogmentasyonu, çekim soketi şekillendirilmesinde de kök hücre temelli klinik araştırmalar gerçekleştirilmektedir. Henüz kliniğe geçmemekle birlikte, mezenkimal kök hücreler diş eti çekilmesi, osteonekroz temporamandibular eklem hasarlarının ve alveolar sinir yaralanmalarının tedavisi amacı ile hayvan modellerinde araştırmalar devam etmektedir. Ayrıca dental ve oral dokulardan elde edilen mezenkimal kök hücreler, tıbbın başka alanlarında rejeneratif ve immün modülasyon amaçlı kullanılmaktadır. Kök hücre uygulamalarında biyo-mühendislik ile işbirliği yapılarak uygun doku iskeleleri kullanarak istenilen dokunun rejenerasyonu mümkün görünmektedir. Biyolojik olarak diş (biyo-diş/biyo-kök) elde edilmesi, küçük ve büyük hayvan modellerinde başarılı ile elde edilebilmiştir. İnsan hücreleri ile yapılan biyo-diş araştırmaları hayvan modellerine/hücrelerine kıyasla daha az öngörülebilir olmakla birlikte, çalışmalar devam etmektedir.

Name: SEMA S. HAKKI

Date of Birth: April 14, 1972

EDUCATION:

1999-2000    :Science Fellowship (Post-doctorate). University of Michigan, Faculty of Dentistry, Department of Periodontics/Prevention/Geriatrics, Ann Arbor, Michigan, USA.

1995-1999     :Ph.D., Hacettepe University, Faculty of Dentistry, Department of Periodontology, Ankara, Turkey

1989-1994    :Doctor of Dental Surgery, Hacettepe University, Faculty of Dentistry, Ankara, Turkey

 

TEACHING EXPERIENCES:

  1. rn
  2. : Hacettepe University, Faculty of Dentistry-Teaching Assistant
  3. rn

2002-2006    : Selcuk University, Faculty of Dentistry-Assistant Professor

2006-2011    : Selcuk University, Faculty of Dentistry-Associate Professor

2011-           : Selcuk University, Faculty of Dentistry-Professor

 

University Activities

2012-2015: Faculty Council

2012-2015: The member of Selcuk University Senate

2019-       : Faculty Council

rnrnrn rn rn rn rn rn rn

   

 

 

AWARDS & HONORS :

2018………….:Second Place Oral Presentation Award’ 48.Turkish Society of   Periodontology, Antalya, TURKEY, 2018

2018          :’First Place’ Oral Presentation, YUDBAT, Yeditepe University, 7th National 5th International Student Research Days, 13-14 April 2018, Istanbul, TURKEY Students; Ahmet Oğuz AYDOĞDU, Mehmet Eren GÜNNER, Supervisors: Isa Yontem, Sema S. Hakki, Comparison of Biocompatibilities among the polyetheretherketones (PEEK) and different gold standard base materials,

2017     :‘The Best Poster Award’ 47th Scientific Congress of Turkish Society of   Periodontology, İstanbul, Turkey.

2016         : Third Place Oral Presentation Award’ 46.Turkish Society of Periodontology,       Izmir, TURKEY, 2016.

2015          : Third Place Oral Presentation Award’ 45.Turkish Society of Periodontology,       Ankara, TURKEY, 2015.

2014     : ‘The Best Poster Award’ 44th Scientific Congress of Turkish Society of Periodontology, İstanbul, Turkey.

2012             :’Second Place Poster Award’ International Team of Implantology Congress, Ankara, Turkey

2011             : ‘The Best Poster Award’ ‘Periodontal Regeneration: Current and Future Aspects’ Symposium, June 9-10, 2011, Konya, Turkey

2010             :‘Third Place Oral Presentation Award’ 40.Turkish Society of Periodontology, İzmir, TURKEY, 2010.

2010            : The best manuscript of the year in Acta Odontologica Scandinavica.

2009             : ‘The Best Poster Award’ 5th Congress of the International Society for Oral Laser Applications SOLA, October 22nd–25th, 2009 LASER CONGRESS, Vienna, Austria

2008             :Award for Scientific Research in Periodontology (First Place Award) 38th Scientific Congress of Turkish Society of Periodontology, Istanbul, Turkey.

2001-2002    :The Scientific and Technical Research Council of Turkey (TUBITAK)

1999-2000    :The Scientific and Technical Research Council of Turkey (TUBITAK-NATO B1) - Science Fellowships

1998             :BANAT Award for Scientific Research in Periodontology (First Place Award) 28th Scientific Congress of Turkish Society of Periodontology. Kizilcahamam, Ankara, Turkey.

PhD Thesis: Effects of basic-Fibroblast Growth Factor and Dexamethasone on the Proliferation, Protein Content and Type I Collagen mRNA Expression of Periodontal Ligament Cells.

Supervisor: Prof. Dr. Rahime M. NOHUTCU (Hacettepe University)

MEMBERSHIPS:

Turkish Society of Periodontology (1996-    )

Turkish Society of Biotechnology (2003-    )

International Association for Dental Research (IADR) (2000-    )

Continental European Division of IADR (CED) (2005-    )

European Federation of Periodontology (EFP) (2002-    )

International Team for Implantology (ITI fellow) (2010-   )

International Society for Oral Laser Applications (SOLA) (2009-   )

European Association for Osseointegration (EAO) (2014)

Turkish Society of Medical Biology and Genetic (2017-    )

Society of Stem Cell and Cellular Treatments (2014-    )

 

 

Researcher ID: Y-2878-2018

https://orcid.org/0000-0001-8665-6235

 

 

RESEARCH ACTIVITIES:

 

1) The Scientific and Technical Research Council of Turkey (TUBITAK Project, SBAG-119R008, 2019-2021. Biomimetic Porous Dental Implant Design, Invivo and Invitro Evaluation

 

2) The Scientific and Technical Research Council of Turkey (TUBITAK Project, (UIDB) SBAG-BMBF 114S543 2015-2018. Identification of Shared Genetic Risk Variants of Aggressive Periodontitis Among Turkish and German Populations

 

3) The Scientific and Technical Research Council of Turkey (TUBITAK Project, SBAG-114S389, 2014-2016. Effects of boric acid on the mineralization potentials of pulps cells.

 

4)The Scientific and Technical Research Council of Turkey (TUBITAK Project, SBAG-112S587, 2013-2015. Comparison of the migration of mesenchymal stem cells isolated from different tissues: The effect of basic-Fibroblast Growth Factor (b-FGF; FGF2) and Stromal Cell Derived Factor-1 (SDF-1) on the migration of cells

 

5) The Scientific and Technical Research Council of Turkey (TUBITAK Project SBAG-110S415), 2011-2013. The role of miRNAs during osteogenic differentiation of human tooth-pulp and periodontal ligament-derived stem cells

6) The Scientific and Technical Research Council of Turkey (TUBITAK Project, (UIDB) SBAG-BMBF-7(108S265), 2009-2010. Comparison of the effects of natural and recombinant forms of amelogenin on cementoblasts and periodontal ligament fibroblasts’ (with Bonn University)

7) The Scientific and Technical Research Council of Turkey (TUBITAK Project, SBAG-107S379, 2008-2010. Gingival Recession Treatment Using Tissue Engineering Technique

8) The Scientific and Technical Research Council of Turkey (TUBITAK Project SBAG-3437(106S189)2006-2008     The Evaluation of Cytotoxicity of Glass-Ionomer Cements using Dentin Barrier Test.

9) The Scientific and Technical Research Council of Turkey (TUBITAK Project SBAG-HD-188 2007-2008 Evaluation of periodontal Status of Lichen Planus Patients.

10) National Boren Research Institute (BOREN-2006-08-Ç07) 2006-2008 ‘The Effects of Boron on the Bone Formation and signaling pathways’

11) The Scientific and Technical Research Council of Turkey (TUBITAK Project, SBAG-3130): 2005-2008. Different Titanium Surfaces and Cells Interactions.

12) Selcuk University, Scientific Research Coordination Office Project 2003-071: 2003-2005. "Comparison of the Effects of Two Different Canine Distalization Methods on Gingival Crevicular Fluid (GCF) Level of Matrix MetalloProteinases (MMP), Tissue Inhibitors of Matrix MetalloProteinases (TIMP), Prostaglandin E2 (PGE2) and Interleukin-1b (IL-1b)"

 

13) Selcuk University, Scientific Research Coordination Office Project 2003-070: 2003-2006. "The Effects of Platelet Rich Plasma, Growth and Differentiation Factors on  the Proliferation, Mineralization and Mineralized Tissue Markers mRNA Gene Expression of the Gingival Fibroblasts, Periodontal Ligament Cells and Osteoblasts, In vitro"

 

14) The Scientific and Technical Research Council of Turkey (TUBITAK Project, SBAG-2648): 2003-2006. "The profile of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors Metalloproteinases (TIMPs) Gene Expressions on the Human Periodontal Ligament (PDL) Cells and the Effects of basic-Fibroblast Growth Factor (b-FGF) and/or Dexamethasone (Dex) on the enzyme profile"

 

15) Selcuk University, Scientific Research Coordination Office Project 2002-190: 2002-2005. "The Effects of Growth Factors on the Matrix MetalloProteinases (MMP) and Tissue Inhibitors of Matrix MetalloProteinases (TIMP) mRNA Gene Expression of the Periodontal Ligament (PDL) Cells In vitro"

 

16) Selcuk University, Scientific Research Coordination Office Project 2002-105: 2002-2005. "The Evaluation of the Effects of basic-Fibroblast Growth Factor (b-FGF) and Dexamethasone (Dex) on the Gene Expression of Extracellular Matrix Proteins in Periodontal Ligament (PDL) Cells via Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR), in vitro"

 

17) Hacettepe University Research Foundation: 2001-2004. "The Effects of basic-Fibroblast Growth Factor (b-FGF) and Dexamethasone (Dex) on the Mineralized Tissue Gene Expressions of Cementoblasts and Periodontal Ligament Fibroblasts and Investigation of Signaling Pathways.

 

18) The Scientific and Technical Research Council of Turkey: 2001-2002. The Effects of basic-Fibroblast Growth Factor (b-FGF) and Dexamethasone (Dex) on the Mineralized Tissue Gene Expressions of Cementoblasts and Periodontal Ligament Fibroblasts.

 

19)The Scientific and Technical Research Council of Turkey: 1999-2000. "The Effects of Growth Factors on Periodontal Regeneration"

 

20) Hacettepe University Research Foundation: 99T 05102001/1999-2000. "The Effects of Growth Factors on Human Periodontal Ligament Cells"

 

21) State Planning Organization of Turkey (DPT): 97K121250/1998-1999. "The Expression of Mineralized Tissue Proteins on the Human Periodontal Ligament Cells and Their Role in the Periodontal Regeneration."

 

 

PUBLICATION:

1. Hakki S.S., Berry J.E., Somerman M.J. The Effects of Enamel Matrix Derivatives (EMD) on Follicle Cells In vitro’’, J Periodontol 2001; 72: 550-558.

2. Berry, J.E., Hakki S.S., Zhao M., McCauley L.K., Somerman M.J. Characterization of Murine Dental Follicle Cells. J Dent Res 2001; 80: 488

3. Hakki S.S., Nazliel (Celenligil)H., Karaduman A., Usubutun A., Ertoy D., Ayhan A., Ruacan S. Epidermolysis Bullosa Acquisita: Clinical Manifestations, Microscopic Findings and Surgical Periodontal Therapy: A case report. J Periodontol 2001; 72: 679-687.

4. Somerman M.J., Viswanathan H., Berry J.E., Giannobile W.V., Ouyang H.J., Nohutcu R.M., Hakki S.S., Zhao M., McCauley L.K. Periodontal Regeneration: Bridging the  Gap between Clinical Practice and Basic Research. In Periodontal Tissue Destruction and Remodeling. Tuncer O, Mutlu S, Scully C, eds. Quintessence, Chicago, IL, 2003, 121-133.

5. Hakki S.S., Aprikyan A.G., Yildirim S., Aydinbelge M., Gokalp A., Guran S., Koseoglu V., Ataoglu T., Somerman M.J. Periodontal Status in Two Siblings with Severe Congenital Neutropenia: Diagnosis and Mutational Analysis of the Cases. J Periodontol 2005; 76: 837-844.

6. Hakki S.S., Ataoglu T., Avunduk M.C., Erdemli E., Gunhan O., Rahman N. Two Siblings with Juvenile Hyaline Fibromatosis: Periodontal Treatment. J Clin Periodontol 2005; 32, 1016-1021

7. Hakki S.S., Nohutcu R.M., Hakki E.E., Berry J.E., Akkaya M.S., Somerman M.J. Dexamethasone (Dex) and basic-Fibroblast Growth Factor (b-FGF) Regulate Markers of Mineralization in Cementoblasts In vitro. J Periodontol 2005; 76: 1550-1558

8. Cagli N.A., Hakki S.S., Dursun R., Toy H., Gokalp A., Ryu Q.H., Hart P.S., Hart T.C. Clinical, genetic and biochemical findings in two siblings with Papillon-Lefèvre Syndrome. J Periodontol 2005; 76: 2322-2329

9. Hakki S.S., Balci B., Hakki E.E., Yılmaz E., Nohutcu R.M. Identification of the Difference in Extracellular Matrix and Adhesion Molecules of Cultured Human Gingival Fibroblasts versus Juvenile Hyaline Fibromatosis-Gingival Fibroblasts using cDNA Microarray Analysis. J Periodontol 2005; 76: 2244-2253

10. Hakki S.S., Wang D., Franceschi R.T., Somerman M.J. Bone sialoprotein gene transfer to periodontal ligament cells may not be sufficient to promote mineralization, in vitro or in vivo. J Periodontol, 2006; 77: 167-173

11. Sengun A., Buyukbas S., Hakki S.S. Evaluation of Cytotoxic Effects of Dental Desensitizers on Human Gingival Fibroblasts. J Biomed Mater Res B Appl Biomater, 2006 ;78:131-137

12. Emecen P, Akman AC, Hakki SS, Hakki EE, Demiralp B, Tözüm TF, Nohutcu RM. ABM/P-15 modulates proliferation and mRNA synthesis of growth factors of periodontal ligament cells. Acta Odontol Scand. 2009;67(2):65-73.

13. Ustun K, Alptekin NO, Hakki SS, Hakki EE. Investigation of matrix metalloproteinase-1--1607 1G/2G polymorphism in a Turkish population with periodontitis. J Clin Periodontol. 2008 Dec;35(12):1013-9.

14. Ustun K, Sari Z, Orucoglu H, Duran I, Hakki SS. Severe gingival recession caused by traumatic occlusion and mucogingival stress: a case report. Eur J Dent. 2008 Apr;2(2):127-33.

15. Korkusuz P, Hakki SS, Purali N, et al. Interaction of MC3T3-E1 cells with titanium implants. JOINT DISEASES AND RELATED SURGERY, 2008; 19(2): 84-90

16. Hakki SS, Berk G, Dundar N, Saglam M, Berk N. Effects of root planing procedures with hand instrument or erbium, chromium:yttrium-scandium-gallium-garnet laser irradiation on the root surfaces: a comparative scanning electron microscopy study. Lasers Med Sci. 2009 Feb 14. [Epub ahead of print]

17. Hakki SS, Bozkurt SB, Hakki EE, Belli S.Effects of mineral trioxide aggregate on cell survival, gene expression associated with mineralized tissues, and biomineralization of cementoblasts. J Endod. 2009 Apr;35(4):513-9

18. Hakki SS, Hakki EE, Nohutcu RM. Regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by basic fibroblast growth factor and dexamethasone in periodontal ligament cells. J Periodontal Res. 2009 Dec;44(6):794-802

19. Hakki SS, Korkusuz P, Berk G, Dundar N, Saglam M, Bozkurt B, Purali N.Comparison of Er,Cr:YSGG laser and hand instrumentation on the attachent of periodontal ligament fibroblasts to periodontally diseased root surfaces: an in vitro study. J Periodontol. 2010 Aug;81(8):1216-25.

20. Hakki SS, Foster BL, Nagatomo KJ, Bozkurt SB, Hakki EE, Somerman MJ, Nohutcu RM. Bone morphogenetic protein-7 enhances cementoblast function in vitro. J Periodontol. 2010 Nov;81(11):1663-74.

21. Hakki SS, Bozkurt BS, Hakki EE. Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3T3-E1).J Trace Elem Med Biol. 2010 Oct;24(4):243-50.

22. Kurt-Sukur ED, Turul-Ozgur T, Yaprak E, Hakki SS, Sanal O. Gingivitis and Very High IgE Level in a Chronic Granulomatous Disease Patient with Unusual Presentation: A Case Report. Pediatric Allergy, Immunology, and Pulmonology. 2011, 24(3): 171-174.

23. Hakki SS, Bozkurt SB. Effects of different setting of diode laser on the mRNA expression of growth factors and type I collagen of human gingival fibroblasts.Lasers Med Sci. 2012 Mar;27(2):325-31.

24. Sengün A, Yalçın M, Ülker HE, Öztürk B, Hakkı SS. Cytotoxicity evaluation of dentin bonding agents by dentin barrier test on 3-dimensional pulp cells.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):e83-8.

25. Öztürk F, Malkoc S, Ersöz M, Hakki SS, Bozkurt BS. Real-time cell analysis of the cytotoxicity of the components of orthodontic acrylic materials on gingival fibroblasts.Am J Orthod Dentofacial Orthop. 2011 Nov;140(5):e243-9.

26. Hakki SS, Bozkurt SB, Ozcopur B, Purali N, Belli S.Periodontal ligament fibroblast response to root perforations restored with different materials: a laboratory study. Int Endod J. 2012 Mar;45(3):240-8.

27. Malkoç S, Öztürk F, Çörekçi B, Bozkurt BS, Hakki SS. Real-time cell analysis of the cytotoxicity of orthodontic mini-implants on human gingival fibroblasts and mouse osteoblasts.Am J Orthod Dentofacial Orthop. 2012 Apr;141(4):419-26.

28. Hakki SS, Bozkurt SB, Hakki EE, Korkusuz P, Purali N, Koç N, Timucin M, Ozturk A, Korkusuz F. Osteogenic differentiation of MC3T3-E1 cells on different titanium surfaces. Biomed Mater. 2012 Aug;7(4):045006. doi: 10.1088/1748-6041/7/4/045006. Epub 2012 May 8.

29. Hakki SS, Dundar N, Kayis SA, Hakki EE, Hamurcu M, Kerimoglu U, Baspinar N, Basoglu A, Nielsen FH.Boron enhances strength and alters mineral composition of bone in rabbits fed a high energy diet. J Trace Elem Med Biol. 2013 Apr;27(2):148-53.

30. Hakki SS, Bozkurt BS, Ozcopur B, Gandolfi MG, Prati C, Belli S.The response of cementoblasts to calcium phosphate resin-based and calcium silicate-based commercial sealers. Int Endod J. 2013 Mar;46(3):242-52.

31. Kebapcilar L, Hakki SS. Letter to the editor: re: role of smoking and type 2 diabetes in the immunobalance of advanced chronic periodontitis. J Periodontol. 2012 Oct;83(10):1204-1205.

32. Hakki SS, Korkusuz P, Purali N, Korkusuz F, Bozkurt BS, Hakki EE, Onder ME, Gorur I, Nohutcu RM, Timucin M, Ozturk A. Periodontal ligament cell behavior on different titanium surfaces. Acta Odontol Scand. 2013 May-Jul;71(3-4):906-16.

33. Sağlam M, Arslan U, Bozkurt SB, Hakki SS. Boric Acid Irrigation as an Adjunct to Mechanical Periodontal Therapy in Chronic Periodontitis Patients: A Randomized Clinical Trial.J Periodontol. J Periodontol. 2013 Sep;84(9):1297-308.

34. Köseoğlu S, Duran I, Sağlam M, Bozkurt SB, Kırtıloğlu OS, Hakki SS. Efficacy of Collagen Membrane Seeded With Autologous Gingival Fibroblasts in Gingival Recession Treatment: A Randomized, Controlled Pilot Study. J Periodontol. 2013 Oct;84(10):1416-24.

35. Ertugrul AS, Dursun R, Dundar N, Avunduk MC, Hakki SS. MMP-1, MMP-9, and TIMP-1 levels in oral lichen planus patients with gingivitis or periodontitis. Arch Oral Biol. 2013 Jul;58(7):843-52.

36. Hakki SS, Ataoğlu T, Hakki EE, Kayis SA. Letters to the editor: re: "real-time quantitative polymerase chain reaction analysis of patients with refractory chronic periodontitis". J Periodontol. 2013 Mar;84(3):275-276.

37. Yalçin M, Barutcigil C, Umar I, Bozkurt BS, Hakki SS. Cytotoxicity of hemostatic agents on the human gingival fibroblast. Eur Rev Med Pharmacol Sci. 2013 Apr;17(7):984-8.

38. Seckin Ertugrul A, Arslan U, Dursun R, Hakki SS. Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis. Int J Oral Sci. 2013 Jun;5(2):92-7.

39. Hakki SS, Korkusuz P, Purali N, Bozkurt B, Kus M, Duran I. Attachment, proliferation and collagen type I mRNA expression of human gingival fibroblasts on different biodegradable membranes. Connect Tissue Res. 2013;54(4-5):260-266

40. Hakki SS, Demiralp B, Buyukozdemir Askin S, Nohutcu RM. Effects of Dentin Exracts on Human Periodontal Ligament Cells in vitro. Türkiye Klinikleri J Dental Sci 2013; 19(1):1-8

41. Hakki SS, Bozkurt B, Hakki EE, Kayis SA, Turac G, Yilmaz I, Karaoz E. Bone morphogenetic protein-2, -6, and -7 differently regulate osteogenic differentiation of human periodontal ligament stem cells. J Biomed Mater Res B Appl Biomater. 2014 Jan;102(1):119-30.

42. Toy E, Malkoc S, Corekci B, Bozkurt BS, Hakki SS. Real-time cell analysis of the cytotoxicity of orthodontic brackets on gingival fibroblasts. J Appl Biomater Funct Mater. 2014 Dec 30;12(3):248-55.

43. Saglam M, Akman S, Malkoç S, Hakki SS. Modification Of Maxillary Sinus Floor With Orthodontic Treatment and Implant Therapy: A Case Letter. J Oral Implantol. 2014 Oct;40(5):619-22.

44. Saglam M, Kantarci A, Dundar N, Hakki SS. Clinical and biochemical effects of diode laser as an adjunct to nonsurgical treatment of chronic periodontitis: a randomized, controlled clinical trial. Lasers Med Sci. Lasers Med Sci. 2014 Jan;29(1):37-46.

45. Yavas G, Yavas C, Bozkurt B, Ata O, Hakki SS. Ionizing Radiation Induces Cytokines, MMP-1, TIMP-1 and Supresses Type I Collagen mRNA Expressions in Human Gingival Fibroblasts. International Journal of Hematology and Oncology/Uluslararası Hematoloji-Onkoloji Dergisi, 2014; 24(3): 149-156

46. Dolanmaz D, Saglam M, Inan O, Dundar N, Alniacık G, Gursoy Trak B, Kocak E, Hakki SS. Monitoring bone morphogenetic protein-2 and -7, soluble receptor activator of nuclear factor-κB ligand and osteoprotegerin levels in the peri-implant sulcular fluid during the osseointegration of hydrophilic-modified sandblasted acid-etched and sandblasted acid-etched surface dental implants. J Periodontal Res. 2015 Feb;50(1):62-73

47. Yalcin M, Ahmetoglu F, Sisman R, Bozkurt B, Hakki SS. Cytotoxicity of low-shrink composites with new monomer technology on bovine dental pulp-derived cells. Hum Exp Toxicol. 2015 Jan;34(1):93-9.

48. Hakki SS, Kayis SA, Hakki EE, Bozkurt SB, Duruksu G, Unal ZS, Turaç G, Karaoz E. Comparison of mesenchymal stem cells isolated from pulp and periodontal ligament. J Periodontol. 2015 Feb;86(2):283-91.

49. Hakki SS, Malkoc S, Dundar N, Kayis SA, Hakki EE, Hamurcu M, Baspinar N, Basoglu A, Nielsen FH, Götz W.Dietary boron does not affect tooth strength, micro-hardness, and density, but affects tooth mineral composition and alveolar bone mineral density in rabbits fed a high-energy diet. J Trace Elem Med Biol. 2015 Jan;29:208-15.

50. Malkoç MA, Demİr N, Şengün A, Bozkurt ŞB, Hakki SS. Cytotoxicity of temporary cements on bovine dental pulp-derived cells (bDPCs) using realtime cell analysis. J Adv Prosthodont. 2015 Feb;7(1):21-6.

51. Arslan Malkoç M, Demir N, Şengün A, Bozkurt ŞB, Hakki SS. Cytotoxicity evaluation of luting resin cements on bovine dental pulp-derived cells (bDPCs) by real-time cell analysis.Dent Mater J. 2015;34(2):154-60

52. Yolcu Ü, Alan H, Malkoç S, Bozkurt ŞB, Hakki SS. Cytotoxicity Evaluation of Bioresorbable Fixation Screws on Human Gingival Fibroblasts and Mouse Osteoblasts by Real-Time Cell Analysis.J Oral Maxillofac Surg. 2015 Aug;73(8):1562.e1-1562.e10.

53. Gümüşderelioğlu M, Tunçay EÖ, Kaynak G, Demirtaş TT, Aydın ST, Hakkı SS. Encapsulated boron as an osteoinductive agent for bone scaffolds. J Trace Elem Med Biol. 2015 Jul;31:120-8.

54. Ok E, Adanir N, Hakki SS. Comparison of cytotoxicity of various concentrations of origanum exract solution with 2% chlorhexidine gluconate and 5.25 % sodium hypochlorite. European Journal of Dentistry 2015;9(1):6-10

55. Ersoz M, Malkoc S, Bozkurt SB, Hakki SS. Biocompatibility evaluation of orthodontic composite by real-time cell analysis. Hum Exp Toxicol. 2015 Oct 1. pii: 0960327115607944. [Epub ahead of print]

56. Grimm WD, Giesenhagen B, Hakki SS, Schau I, Sirak S, Sletov A. Varga G, Vukovic MA, Widera D. Translational Research for Therapeutic Applications of Stem Cell Transplantation for Periodontal Regeneration. Curr Oral Health Rep, 2016 DOI 10.1007/s40496-015-0067-6

57. Kocak E, Saglam, Kayıs SA, Kebapcilar L, Dundar N, Loos BG, Hakki SS. Non-Surgical Periodontal Therapy with/without Diode Laser Modulates Metabolic Control of Type 2 Diabetics with Periodontitis: A Randomized Clinical Trial. Lasers Med Sci. 2016 Feb;31(2):343-53.

58. Bozkurt SB, Hakki SS, Hakki EE, Durak Y, Kantarci A. Porphyromonas gingivalis Lipopolysaccharide Induces a Pro-inflammatory Human Gingival Fibroblast Phenotype. Inflammation. 2017 Feb;40(1):144-153

59. Dundar S, Eltas A, Hakki SS, Malkoc S, Uslu MO, Tuzcu M, Komorowski J, Ozercan IH, Akdemir F, Sahin K. Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis. Drug Des Devel Ther. 2016 Nov 15;10:3771-3778

60. Hakki SS, Tatar G, Dundar N, Demiralp B. The effect of different cleaning methods on the surface and temperature of failed titanium implants: an in vitro study. Lasers Med Sci. 2017 Apr;32(3):563-571.

61. Bozkurt SB, Hakki EE, Kayis SA, Dundar N, Hakki SS. Biostimulation with diode laser positively regulates cementoblast functions, in vitro. Lasers Med Sci. 2017 May;32(4):911-919

62. Hakki SS, Turaç G, Bozkurt SB, Kayis SA, Hakki EE, Şahin E, Subaşı C, Karaoz E. Comparison of Different Sources of Mesenchymal Stem Cells: Palatal versus Lipoaspirated Adipose Tissue. Cells Tissues Organs. 2017;204(5-6):228-240.

63. Hakki SS, Bozkurt SB, Türkay E, Dard M, Purali N and Götz W. Recombinant amelogenin regulates the bioactivity of mouse cementoblasts in vitro. Int J Oral Sci. 2018 May 9;10(2):15.

 

PRESENTATION AT INTERNATIONAL CONGRESS:

1. Nohutçu R. M., Hakki S. S., Demiralp B., Eratalay Y. K. Effects of  Dentin Extracts on Mineralization of Human Periodontal Ligament Cells In vitro. 76th General Session of IADR. Nice, France, June 24-27, 1998.

2. Hakki S. S., Demiralp B., Eratalay Y. K., Nohutçu R. M. In vitro Mineralization of Periodontal Ligament Cells. 6th International Congress of Turkish Association of Oral and Maxillofacial Surgeons. Belek / Antalya,Turkey.  October 28 – November 1 , 1998.

3. Hakki S. S., Hakki E. E., Akkaya M. S., Nohutcu R. M. The Effects of basic-Fibroblast Growth Factor(b-FGF) on Periodontal Ligament Cells. 78th General Session of IADR. Washington, DC, USA. April 5-8, 2000.

4. Demiralp B., Hakki S. S., Nohutçu R. M. The Effects of Growth Factors on the Periodontal Ligament Cells in vitro. 78th General Session of IADR. Washington, DC, USA. April 5-8, 2000.

5. Somerman M. J., Giannobile W.V., Berry J.E., Viswanathan H., Hakki S.S., Zhao M., Fribley A., Reddi A. Cues from Development of the Periodontium for Regenerating Periodontal Tissues. Symposium on Tissues Engineering. (TETU), Tokyo, Japan, November 16-17, 2000.

6. Somerman M.J., Giannobile W.V., Berry J.E., Viswanathan H., Hakki S.S., Zhao M., Fribley A., Reddi A., Tokiyasu Y. Defining the Cells and Factors Required for Regenerating Periodontal Tissues from in vitro to in vivo. Symposium at the Medical and Dental College (Basic to Clinical), Tokyo, Japan, November 16-17, 2000.

7.  Berry J.E., Hakki S.S., Zhao M., McCauley L.K., Somerman M.J. Characterization of Murine Dental Follicle Cells. 30th Annual Meeting and Exhibition of AADR, Chicago, IL, USA. March 7-10, 2001.

8.  Hakki S.S., Wang D., Franceschi R.T., Somerman M.J. Gene Transfer of Bone Sialoprotein (BSP) to Periodontal Ligament Cells: Role of BSP in Periodontal Tissue Engineering and Regeneration. IXth International Symposium on Biomedical Science and Technology, Kemer, Antalya, Turkey. September 19-22, 2002.

9.  Hakki S.S., Nohutcu R.M., Hakki E.E., Berry J.E., Somerman M.J. Effect of b-FGF and Dexamethasone in Cementoblasts. Europerio 4, Berlin, Germany. June 19-21, 2003.

10.  Cagli N.A., Hakki S.S., Ataoglu T. Intentional Replantation of Hopeless Teeth. 9th Congress of the Balkan Stomatological Society, Ohrid, May 13-16, 2004.

11. Atici K., Hakki S.S. Effect of combined antibiotic therapy on gingival crevicular fluid enzymes. Continental European Division of the International Association for Dental Research, Istanbul, August 25-28, 2004.

12. Hakki S.S., Nohutcu R.M., Somerman M.J. b-FGF Amplifies Effect of Dexamethasone on the PDL Cell Mineralization. Continental European Division of the International Association for Dental Research, Istanbul, August 25-28, 2004.

13. Sengun A., Hakki S.S. Evaluation of Cytotoxic Effects of Desensitizers on Human Gingival Fibroblast Cells. Continental European Division of the International Association for Dental Research, Istanbul, August 25-28, 2004.

14. Hakki S.S., Balci B., Hakki E.E., Yılmaz E., Nohutcu R.M. Comparison of Extracellular Matrix and Adhesion Molecules mRNA Expression in Cultured Human Gingival Fibroblasts with Juvenile Hyaline Fibromatosis Gingival Fibroblasts by cDNA Microarray Analysis. Biomed 2004, 11th International Biomedical Science and Technology Days, Ankara, September 6-10, 56, 2004.

15. Hakki S.S., Balci B., Hakki E.E., Yilmaz E., Nohutcu R.M. Identification of Genes Differentially Expressed in Gingival Fibroblasts versus Periodontal Ligament Fibroblasts. 83th General Session of IADR, Baltimore, MD, USA. March 12-15, 2005.

16. Hakki S.S., Nohutcu R.M., Somerman M.J. BMP-7 Regulates Extracellular Matrix Profile and Mineralization of Cementoblasts. Annual Meeting of the Continental European Division (CED) and Scandinavian Division (NOF) of IADR, Amsterdam, Netherlands, September 14-17, 2005

17. Cagli N.A., Hakki S.S., Satana B., Ataoglu T. Six Months Results of Intentional Replantation of Periodontally Hopeless Teeth. Annual Meeting of the Continental European Division (CED) and Scandinavian Division (NOF) of IADR, Amsterdam, Netherlands, September 14-17, 2005

18.  Emecen P., Akman A.C., Özer Ö., Hakki E.E., Demiralp B., Hakki S.S., Nohutcu R.M. The Effect of Pepgen in Periodontal Ligament Cells, in vitro. Annual Meeting of the Continental European Division (CED) and Scandinavian Division (NOF) of IADR, Amsterdam, Netherlands, September 14-17, 2005.

19. Buyuközer H, Cagli NA, Kont Cobankara F, Hakki SS.  Replantation of Avulsed Central Incisor Using Tetracycline-HCL: A Case Report. Balkan Stomatological Society 11th Congress of the BaSS, Sarajevo, May 11-14, 2006

20. Hakki SS, Hakki EE, Nohutcu RM.  b-FGF Regulates MMP and TIMP mRNA Expressions of PDL Cells. Europerio 5, Madrid, Spain, 29 June-1 July, 2006.

21. Duran I, Ozdemir M, Okudan N, Hakki SS. The Effect of Behçet’s Disease on the Clinical Periodontal Status and Amount of Gingival Crevicular Fluid. Europerio 5, Madrid, Spain, 29 June-1 July, 2006.

22. Duran I, Enhos S, Ustun K, Caliskan U, Hakki SS. Bernard Soulier Syndrome with Prolonged Gingival Bleeding. Europerio 5, Madrid, Spain, 29 June-1 July, 2006.

23. Hakki SS, Duran I, Ustun K, Aktas D, Avunduk MC. Dental and Histopathological Findings of Ehler-Danlos Syndrome. Balkan Stomatological Society 11th Congress of the BaSS, Sarajevo, May 11-14, 2006.

24. Hakki SS, Foster BL, Geurtsen P, Nohutcu RM, Somerman MJ. Effect of BMP-7 on the mineralized tissue markers of cementoblasts. 85th General Session of IADR, New Orleans, Lousiana USA. March 21-24, 2007.

25. Ustun K, Alptekin NO, Haliloglu S, Hakki SS, Hakki EE. MMP-1 -1607 Polymorphism and Periodontitis Susceptibility in a Turkish Population 85th General Session of IADR, New Orleans, Lousiana USA. March 21-24, 2007.

26. Ertugrul AS, Dursun R, Hakki SS. Lichen Planus: Is there a role of dentists in diagnosis? Annual Meeting IADR- Continental European and Israeli Devision. Thessaloniki September 26-29, 2007.

27. Sema S. Hakki, Feza Korkusuz, Petek Korkusuz, Nuhan Purali, Ercument Onder, Muharrem Timucin, Rahime M. Nohutcu, Adnan Ozturk. Effects of Different Implant Surfaces on Biological Responses of MC3T3-E1 Cells. Academy of Osseointegration (23rd Annual Meeting). Implant Dentistry: A Trip to the Implant. Absract no: 174, page:111 February 28 – March 1, 2008, Boston, MA, USA.

28. Seckin Ertugrul, Ugur Arslan, Recep Dursun, Sema S. Hakki. Investigation of periodontopathogen microorganisms in Lichen Planus Patients. International Dental Exhibiton and Meeting (The No. 1 in Asia Pacific), IDEM Singapur,April 4-6, 2008

29. Hakki SS, Berk G, Dundar N, Saglam M, Berk N. Effects of root planing procedures with hand instrument or erbium, chromium:yttrium-scandium-gallium-garnet laser irradiation on the root surfaces: a comparative scanning electron microscopy study. Mediterranean Oral Laser Congress. May 3-4, 2008, Istanbul, Turkey

30. Sema S. Hakki, Mahir Südemen, Buket Bozkurt, Erdogan E. Hakkı. BMP-7 regulates mineralization of periodontal ligament cells. 86th General Session of IADR, Toronto, Canada. July 2-5, 2008.

31. Seckin Ertugrul, Recep Dursun, Sema S. Hakki. Investigation of MMP-1, MMP-9 and TIMP-1 levels in Lichen Planus. 86th General Session of IADR, Toronto, Canada. July 2-5, 2008.

32. Sengun A, Botsali HE, Yalcin M, Ozer F and Hakki SS. Cytotoxic Effects of Glass Ionomer Cements on Bovine Pulp-Derived Cells. 86th General Session of IADR, Toronto, Canada. July 2-5, 2008.

33. Hakki SS, Korkusuz F, Korkusuz P, Purali N, Bozkurt BS, Hakki EE, Onder O, Gorur I, Nohutcu RM, Timucin M, Ozturk A. NaTi Coating Improves Attachment and Mineralization of PDL Cells. 87th General Session & Exhibition of IADR. Miami, Fla, USA. April 1-4, 2009

34. Kerman G, Korkusuz P, Hakki SS, Purali N, Koc N, Timucin M, Korkusuz F. Observation of MC3T3-E1 Cells Applied Bioceramics by Scanning Electron Microscope and Confocal Microscope,2007 Faenza, Italy.

35. Sema S. Hakki, Nuhan Puralı, Petek Korkusuz, Buket Bozkurt, Ismet Duran. . Culture of human gingival fibroblasts on different biodegradable membranes J Clin Periodontol, (SCI kapsamında), Stockholm, Sweden, June 4-6, 2009.

36. Sema S. Hakki, Buket S.Bozkurt, Erdogan E. Hakki. Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3T3-E1) J Clin Periodontol, (SCI kapsamında), Stockholm, Sweden, June 4-6, 2009.

37. Niyazi, Dundar, Emre Yaprak, Ugur Aslan, Yusuf Durak, Sema S. Hakki. Periodontopathogen profile in aggressive periodontitis patients. J Clin Periodontol, (SCI kapsamında), Stockholm, Sweden, June 4-6, 2009.

38. Sema S. Hakki, S. Buket Bozkurt, Erdogan E. Hakki, Muharrem Timucin, Adnan Ozturk, Feza Korkusuz. Gene expressions of MC3T3-E1 cells on titanium surfaces using PCR microarray. IADR /CED/NOF. 10-12 september, Munich, Germany

39. Hakki SS, Korkusuz P, Berk G, Dundar N, Saglam M, Bozkurt SB, Purali N. Comparison of Er,Cr:YSGG laser and hand instrumentation on the attachment of periodontal ligament fibroblasts to periodontally diseased root surfaces: an in vitro study. 5th Congress of the International Society for Oral Laser Applications SOLA, October 22nd – 25th, 2009 LASER CONGRESS, Vienna, Austria

40. Hakki SS, Bozkurt BS, Dard M, Gotz W. rhAMG enhances mineralized tissue associated proteins of cementoblasts. AADR Annual Meeting, March 3-6, 2010, Washington DC, USA

41. Sema S. Hakkı, Buket Ş. Bozkurt, Erdoğan E. Hakkı ‘Boron Regulates Tuftelin mRNA Expression of MC3T3-E1 Cells’ 4th International Symposium on Trace Elements and Minerals in Medicine and Biology,9-12 June 2010, St.Petesburg, Russia.

42. Uğur Arslan, S. Buket Bozkurt, Erdoğan E.  Hakkı, Duygu Fındık, Sema S. Hakki ‘Boric acid as a promising antibacterial agent for clinical usage’ 4th International Symposium on Trace Elements and Minerals in Medicine and Biology, 9-12 June 2010, St.Petesburg, Russia.

43. Hakki SS, Bozkurt SB, Ozcopur B, Purali N, Korkusuz P, Belli S. Attachment of PDL-Fibroblasts to Root Perforations Restored with Different Materials. 88th General Session & Exhibition of the International Association for Dental Research and the 5th General Session of the Pan European Region of the IADR, July 14-17 2010, Barcelona, Spain

44. Hakki SS, Kutlu HB, Bozkurt SB, Ataman ET, Nohutcu RM. Effects of Dexamethasone and/or BMP-6 on the Cementoblasts, in vitro. 88th General Session & Exhibition of the International Association for Dental Research and the 5th General Session of the Pan European Region of the IADR, July 14-17 2010, Barcelona, Spain

45. Yondem I, Yucel MT, Bozkurt SB, Korkusuz P, Hakki SS. Biocompatibility of a Ceramic Material with Different Surface Finishing Techniques. 88th General Session & Exhibition of the International Association for Dental Research and the 5th General Session of the Pan European Region of the IADR, July 14-17 2010, Barcelona, Spain

46. Ozcopur B, Akman M, Hakki SS, Belli S. Leakage of Perforation Repair-Materials (Comparison of Orthograde and Retrograde Techniques). 88th General Session & Exhibition of the International Association for Dental Research and the 5th General Session of the Pan European Region of the IADR, July 14-17 2010, Barcelona, Spain

47. Yaprak E, Hakki SS, Sanal O, Hatipoglu M. Oral and Periodontal Manifestations of a Patient with Hyperimmunoglobulinaemia-E Syndrome. 88th General Session & Exhibition of the International Association for Dental Research and the 5th General Session of the Pan European Region of the IADR, July 14-17 2010, Barcelona, Spain

48. Götz W, Türkay E, Bozkurt SB, Dard M, Hakki SS. Wirkungen von rekombinantem amelogenin auf menschliche PDL-zellen. Gemeinsame DGP-ARPA-Herbsttagung. Parodontologie 2010, September 17-18 2010, Bonn, Germany

49. Türkay E, Hakki SS, Dard M, Jager A, Konermann A, Götz W. Nachweis des amelogenin-rezeptors LAMP-1 in-vivo und in-vitro. Gemeinsame DGP-ARPA-Herbsttagung. Parodontologie 2010, September 17-18 2010, Bonn, Germany

50. Korkusuz F, Korkusuz P, Hakki SS, Koc N, Timucin M, Ozturk A, Nohutcu R, Onder E, Ozturk A. Sodium titanate coating improves mineralization and differentiation of osteoblasts in vitro. American Academy of Orthopaedic Surgeons 2011 Annual Meeting, February 15-19, 2011, San Diego, California, USA (Abstract Book pp 499-500)(Poster)

51. Hakki SS, Bozkurt SB, Ozcopur B, Gandolfi MG, Prati C, and Belli S. Real-time Analysis of Cytotoxicity of Current Root-Canal Sealers on Cementoblasts. IADR General Session. March 16-19, 2011, San Diago, California, USA.

52. Keçeci A.D, Çobankara Kont F., Hakkı S.S., Çelik K., Sağlam M, Dündar N., Belli S. Evaluation of IL-6 and PGE2 levels in GCF of the teeth with periapical diseases. 15th Biennial Congress of the European Society of Endodontology. September 14th-17th, ESE ROME 2011, Rome, Italy.

53. Yavas G, Yavas C, Bozkurt SB, Ata O, Hakki SS. Radiation induces cytokines and MMPs and reduce type I collagen mRNA expression in human gingival fibroblasts. International MASSC/ISOO Symposium, July 23-25, 2011;19(June):2, Abst no:744, Supportive Care in Cancer, Athens, Greece.

54. Tatar G, Hakki SS, Üşümez S, Sarı Z, Dündar N, Ataoğlu T. Effects of Continuous and Interrupted Orthodontic Force on Gingival Crevicular Fluid MMP-1 and TIMP-1 Levels.  Europerio 7 Viena. June 6-9, 2012

55. Ataoglu T, Hakki SS, Usumez S, Sarı Z, Dündar N. Gingival crevicular fluid Interleukin-1β levels during two different canine distalization methods. Europerio 7 Viena. June 6-9, 2012

56. Hakki EE, Bozkurt SB, Karaoz E, Turac G, Hakki SS. Real –time cell analysis of BMP-2, 6 and 7 on the human periodontal ligament stem cells (hPDLSCs). Europerio 7 Viena. June 6-9, 2012

57. Hakki SS, Koseoglu S, Saglam M, Bozkurt SB, Duran I. Efficacy of collagen membrane seeded with autologous gingival fibroblasts in gingival recession treatment: 12 months follow-up. Europerio 7 Viena. June 6-9, 2012

58. Hakki SS, Hakki EE, Bozkurt SB, Turac G, Karaoz E. BMP-6 regulates osteogenic differentiation of the human periodontal ligament stem cells (hPDLSCs). 15th European Congress on Biotechnology September 23-26, 2012 Istanbul, Turkey.

59. Hakki SS, Kayis SA, Bozkur SB, Hakki EE, Yılmaz I, Karaoz E. Osteogenic and proliferative potentials of mesenchymal stem cells isolated from different teeth. 91 th General Session & Exhibition of IADR. Marh 20-23, 2013 Seattle, WA, USA

60. Hakki SS, Malkoc S, Dundar N, Kayis SA, Hakki EE, Hamurcu M, Baspinar N, Basoglu A, Nielsen FH, Gotz W. Dietary Boron does not affect teeth strength, micro-hardness, and density, but affects mineral composition and alveolar bone mineral density in Rabbits fed a high-energy diet. Fifth International Congress of the Federation of the European Societies for Trace Elements and Minerals; Bridging between new advances and public health issues, May 22-24, 2013, Avignon, France

61. Coskuner S, Dursun R, Alan K, Hakki SS. Laser-assisted periodontal plastic surgery in two cicatricial pemphigoid patients: One year follow-up. FDI 101th Annual World Dental Congress, August 28-31, 2013, Istanbul, Turkey

62. TATAR G, ALPTEKIN NO, HAKKI SS, ATAOGLU T. Periodontal Plastic Surgery for Treatment of Postorthodontic Gingival Recession: Three Cases. FDI 101st Annual World Dental Congress, August 28-31, 2013, ISTANBUL, TURKEY

63. Erbeyoglu AA, Ileri Z, Hakki SS. Laser-assisted gingival tissue procedures before restorative and orthodontic treatments. 46th Meeting of the Continental European Division of the International Association for Dental Research, September 4-7, 2013 Florance/Italy (Poster)

64. Tatar G, Erbeyoglu AA, Hakki SS. Laser-assisted vestibuloplasty: Case series. 46th Meeting of the Continental European Division of the International Association for Dental Research, September 4-7, 2013 Florance/Italy (Poster)

65. Toy E, Inonu E, Hakki SS. Management of Capillary Hemangioma Using Diode Laser: Two-Case Report. 46th Meeting of the Continental European Division of the International Association for Dental Research, September 4-7, 2013 Florance/Italy (Poster)

66.  Hakki SS, Kayis SA, Hakki EE, Bozkurt SB, Duruksu G, Unal ZS, Karaoz E. Comparison of mesenchymal stem cells isolated from pulp and periodontal-ligament. 92nd General Session & Exhibition of the IADR. IADR Africa/Middle East Regional Meeting, June 25-28, 2014, Cape Town, South Africa

67. E. Kocak, M. Saglam, S.A. Kayıs, N. Dundar, L. Kebapcılar, and S.S. Hakki. Diode laser as an adjunct to periodontal treatment in Diabetics. IADR/PER Congress, 10-13 September 2014, Dubrovnik, Croatia.

68. Demiralp B, Hakki SS, Tatar G, Dundar N. Efficacy of different cleaning methods on the titanium surface in failed implants: in vitro study. 23rd European Association for Osseointegration Congress, 25-27 September 2014, Rome, Italy.

69. Hakki SS, Saglam M, Kocak E, Gursoytrak B, Dundar N, Inan O, Dolanmaz D. Is there any effect of anatomical location of dental implants on the BMP-2, -7, rankl and opg levels in peri-implant sulcular fluid during osseointegration. 23rd European Association for Osseointegration Congress, 25-27 September 2014, Rome, Italy.

70. Demirci MF, Ata O, Bozkurt SB, Yavas G, Hakki SS. Radiosensitization in human cervical cancer cells by black bumin (nigella sativa-thymoquinone) MASCC/ISOO Symposium International Supportive Care in Cancer, June 26-28, 2014, Miami, USA.

71. Hakki SS, Bozkurt SB, Kayis SA. Hakki EE, Unlu A, Karaoz E. SDF-1 Promotes Migration of the Deciduous Tooth-stem Cells (DTSCs), 93rd General Session & Exhibition of the IADR, 44th Annual Meeting of the AADR, 39th Annual Meeting of the CADR, March 11-14, 2015, Boston, Massachusetts, USA.

72. Belli S, Eraslan O, Hakki SS, Eskistascioglu G. Effect on post-restoration on stresses in premolar with endodontic-periodontal Lesion.  IADR/AADR/CADR General Session & Exhibition, March 11-14, 2015, Boston, Massachusetts, USA.

73. Inonu E, Danisman F, Hakki SS. Laser-assisted Non-surgical Treatment of Generalized Aggressive Periodontitis: A Case Report, 20th BASS Congress, April 23-26, 2015, Bucharest, Romania

74. Okutan Y, Tuncer I, Hakki SS. Interdisciplinary management of misaligned maxillary anterior teeth with prosthetic and periodontal treatment:  a case report. 20th BASS Congress, April 23-26, 2015, Bucharest, Romania

75. Hakki SS, Bozkurt SB, Kayis SA, Dundar N, Hakki EE. Biostimulation with diode laser positively regulates cementoblasts functions, in vitro, Europerio8, June 3-6, 2015 London, UK (Poster).

76. Hakki SS, Bozkurt SB, Hakki EE, Kayis SA, Turac G, Duruksu G, Karaoz E. Isolation of Palatal Adipose Tissue-Mesenchymal Stem Cells (PAT-MSCs). Europerio8, June 3-6, 2015 London, UK (Poster).

77. Kocak E, Kayis SA, Kebapcilar L, Dundar N, Loos BG, Hakki SS. The effects of nonsurgical periodontal therapy on salivary cytokines in diabetics with chronic periodontitis. Europerio8, June 3-6, 2015 London, UK (Poster).

78. Tuncer I, Alan R, Yucel S, Bozkurt D, Sodan Z, Erbeyoglu AA, Hakki SS. Gingival recession treatment with laterally positioned flap technique: case series. Europerio8, June 3-6, 2015 London, UK (Poster).

79. Kayis SA, Hakkı EE, Bozkurt B, Karaöz E, Hakkı SS. Preliminary Expression Analysis of Global MicroRNA and Biogenesis Pathway in Human Mesenchymal Stem Cells Derived from Periodontal Ligament and Pulp of Molar and Premolar Teeth. The 8th Conference of Eastern Mediterranean Region of International Biometric Society. 11-15 May 2015, Cappadocia, Nevsehir, Turkey

80. Kocak E, Arslan U, Kayıs SA, Kebapcilar L, Loos BG, Hakki SS. Effects of nonsurgical periodontal therapy with/without diode laser on periodontopathogens in diabetics with chronic periodontitis. 47th Meeting of the Continental European Division of the International Association for Dental Research, CED-IADR, 15-17 October 2015, Belek, Antalya, Turkey

81. Yolcu U, SB Bozkurt, Hakki SS. Are titanium fixation screws biocompatible? An in vitro study. 47th Meeting of the Continental European Division of the International Association for Dental Research, CED-IADR, 15-17 October 2015, Belek, Antalya, Turkey.

82. Sema S. Hakki, S. Buket Bozkurt, Seyit Ali Kayis, Gizem Turac, Erdal Karaoz, Erdogan E. Hakki. Gene profiling of pulp-MSCs isolated from deciduous and permanent teeth. 2nd International Congress on Stem Cell and Cellular Therapies.  15-18 October, 2015, Antalya, Turkey

83. Sema S. Hakki, S. Buket Bozkurt, Erdogan E. Hakki, Irem Yılmaz, Erdal Karaoz, Seyit Ali Kayis. Comparison of gene expression profile of Pulp and Periodontal ligament-MSCs. 2nd International Congress on Stem Cell and Cellular Therapies.  15-18 October, 2015, Antalya, Turkey

84. Sema S. Hakki, S. Buket Bozkurt, Erdal Karaoz, Erdogan E. Hakki, Seyit Ali Kayis. bFGF regulates gene profiling of dental-MSCs isolated from deciduous and permanent teeth. EUROBIOTECH 2016, European Biotechnology Congress, 5-7 May 2016. Riga, Latvia

85. Elif İnönü, Gözde Koşun, Recep Dursun, Sema S. Hakki. Periodontal Treatment of Cases with Papillon-Lefevre Syndrome. 21th BaSS Congress, 12-15 May 2016, Banja Luka, Bosnia & Herzegovina.

86. Sema S. Hakki, Niyazi Dundar, Siddik Malkoc, Mehmet Hamurcu, Erdogan E. Hakki, Nuri Baspinar, Abdullah Basoglu, Seyit Ali Kayis. Effects of different boron compounds on the teeth and bone in rabbits fed high protein and energy diet. FESTEM Symposium on Trace Elements and Minerals, 26-28 May, 2016, Catania, Sicily

87. Sema S. Hakki, S. Buket Bozkurt, Erdogan E. Hakki, Erdal Karaoz, Seyit A. Kayis. Comparison of PDL-MSCs and BM-MSCs gene profiles. 94th General Session & Exhibition of the IADR, 3rd Meeting of the IADR Asia Pacific Region, 35th Annual Meeting of Seoul, Korean Division, June 22-25, 2016, Seoul, Republic of Korea

88. Hakki SS, Bozkurt SB, Hakki EE, Karaoz E, Kayis SA. PENK Might Modulate Immunoregulation Properties of Mesenchymal Stem Cells (MSCs). IADR/AADR/CADR, 22-25 March 2017, San Francisco, USA

89. Hakki SS, Bozkurt SB, Hakki EE, Karaoz E, Unlu A, Kayis SA. SDF-1 modulates periodontal ligament-Mesenchymal Stem Cells (pdl-MSCs) functions, in vitro. European Biotechnology Congress 2017, 25-27 May, 2017, Dubrovnik, Crotia

90. Tuncer Gokdag I, Bozkurt SB, Hakki SS. Selenium regulates IL-10 mRNA expression of LPS induced-human periodontal ligament mesenchymal stem cells (hPDL-MSCs). Joint 16th International Symposium on Trace Elements in Man and Animals (TEMA-16), ISTERH 2017 and NTES 2017, 26-29 June, 2017, St Petersburg, Russia

91. Hakki SS, Ergül Z, Kayis SE, Bozkurt SB, Karaoz E. Immuno-regulatory functions of periodontal ligament and pulp stem cells. 47th Annual Meeting of the AADR. March 21-24, 2018, Fort Lauderdale, Fla., USA.

92. Hakki SS, Bozkurt SB. Regulation of enzymes and cytokines profile of cementoblasts with diode laser biostimulation.  June 20-23, Europerio9, 2018 Amsterdam

93. Hakki SS, Tuncer Gokdag I, Bozkurt SB. Porphyromonas gingivalis Lipopolysaccharide (Pg-LPS) regulates mineralized tissue associated genes of hPDL-MSCs 43 rd The Federation of European Biochemical Societies (FEBS) Congress, July 7-12, 2018, Praque, Check Republic

94. Bozkurt SB, Hakki SS, Kantarci A. Resolvin E1 stimulates oxidative stress enzymes of the cementoblasts 43 rd The Federation of European Biochemical Societies (FEBS) Congress, July 7-12, 2018, Praque, Check Republic

95. Hakki SS & Bozkurt SB. Nicotine down-regulates the proliferation of the cementoblasts (OCCM.30). 14th Annual Conference of the International Society for the Prevention of Tobacco Induced Diseases (ISPTID), October 4-6, 2018, İzmir, Turkey

96. Buduneli N, Gurlek O, Meric P, Baser U, Guncu G, Hakki SS, Kuru L, Lutfioglu M, Olgun E, Ozdemir B, Tasdemir Z, Ustun K. What is the rate of tobacco usage among dental school students? 14th Annual Conference of the International Society for the Prevention of Tobacco Induced Diseases (ISPTID), October 4-6, 2018, İzmir, Turkey.

97.  

 

 

National Publications

  1. rn
  2. Hakkı, S.S. ve R.M. Nohutcu, Periodontal Rejenerasyonda Biyolojik Faktörler , Hacettepe Dişhekimliği Fakültesi Dergisi, 26, 12-22 (2002).
  3. rn
  4. Hakkı, S.S. ve R.M. Nohutcu, Periodontal Ligament Hücrelerinin Periodontal Rejenerasyondaki Önemi , Hacettepe Dişhekimliği Fakültesi Dergisi, 26, 23-31 (2002).
  5. rn
  6. Hakkı, S.S., R.M. Nohutcu ve M.J. Somerman,Periodontal Ligament Hücrelerinde Platelet Derived Growth Factor-BB mRNA Ekspresyonunun basic-Fibroblast Growth Factor ve Dexamethasone  ile Regülasyonu  Hacettepe Dişhekimliği Fakültesi Dergisi, 28, 16-23 (2004).
  7. rn
  8. Hakkı, S.S. ve R. M. Nohutcu,Periodontal Doku Mühendisliğinde Gen Tedavisi  Hacettepe Dişhekimliği Fakültesi Dergisi, 28, 35-44 (2004).
  9. rn
  10. Hakkı, S.S., E.E. Hakkı, M.S. Akkaya ve R.M. Nohutcu,Basic-Fibroblast Growth Factor ve Dexamethasone’un Periodontal Ligament Hücrelerinin Proliferasyonu, Protein miktarı ve Tip I Kollajen mRNA Ekspresyonu Üzerine Etkisi , Hacettepe Dişhekimliği Fakültesi Dergisi, 28, 52-67 (2004).
  11. rn
  12. Hakkı, S. S. ve E.E. Hakkı,Dişhekimliğinde Moleküler Biyoloji Tekniklerinin Önemi ve 21. Yüzyıla Bakış, Hacettepe Dişhekimliği Fakültesi Dergisi, 29(4A), 68-81 (2005).
  13. rn
  14. Yavaş, Ö. ve S.S. Hakkı, Onkoloji Hastalarında Oral Komplikasyonlar ve Dental Yaklaşım  Hacettepe Dişhekimliği Fakültesi Dergisi, 29(4A), 58-67 (2005).
  15. rn
  16. Hakkı, S.S., B. Demiralp ve R.M. Nohutcu, Periodontal Rejenerasyon ve Dentin  Hacettepe Dişhekimliği Fakültesi Dergisi, 29(4A), 43-48 (2005).
  17. rn
  18. Ertuğrul, A.S., S.S. Hakkı, T. Ataoğlu, B. Demiralp ve M.C. Avunduk,Periferal Dev Hücreli Granüloma Tedavisi; Bir Olgu Raporu  Hacettepe Dişhekimliği Fakültesi Dergisi , 29 (4A), 49-53 (2005).
  19. rn
  20. Atici, K ve S.S. Hakkı, Effect of combined antibiotic therapy on intracytoplasmic enzyme activities of gingival crevicular fluid  Hacettepe Dişhekimliği Fakültesi Dergisi, 29 (3), 57-64 (2005).
  21. rn
  22. Hakkı, S.S. ve R.M. Nohutcu, basic-Fibroblast Growth Factor (b-FGF) ve Dexamethasone (Dex)’un Pre-osteoblastların (MC3T3-E1) Proliferasyonu, Total Protein Miktarı ve Hücre Morfolojisi Üzerine Etkisi, Hacettepe Dişhekimliği Fakültesi Dergisi, 29 (4), 42-50 (2005).
  23. rn
  24. Duran, İ., N. Okudan, H. Gökbel ve S.S. Hakkı, Obesitenin Klinik Periodontal Parametreler ve Dişeti Oluğu Sıvısı Miktarı Üzerine Etkisi , Hacettepe Üniversitesi Dişhekimliği Fakültesi Dergisi, 29 (4), 62-67 (2005).
  25. rn
  26. Enhoş, Ş., S.S. Hakkı ve M.C. Avunduk, Osifiye Fibrom Tedavisi; Bir Vaka Raporu (2 Yıllık Takip) , yayımlanmak üzere Selçuk Üniversitesi Dişhekimliği Fakültesi Dergisi, 2004; 14(1): 1-4
  27. rn
  28. Hakkı, S.S., R.M. Nohutcu ve M.J. Somerman, Askorbik Asitin Sementoblastların Ekstrasellüler Matriks Proteinlerine Etkisinin Mikroarray cDNA Analizi ile İncelenmesi, Se
Yukarı